UC Santa Cruz study shows psilocybin rewires mouse brains and can do so without psychedelic behavior
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University of California, Santa Cruz researchers report in Nature Neuroscience (15 October) that psilocybin quickly drives new neural connections to form and mature while clearing some older ones. In mice they uncoupled those structural changes from typical psychedelic behavior; effects differed between healthy and chronically stressed animals, suggesting routes to boost neuroplasticity for depression, PTSD, and similar conditions without hallucinations.
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