Scientists identify signaling molecule that causes cancer-fighting T cells to burn out
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Researchers at Memorial Sloan Kettering Cancer Center identified a signaling molecule called MEK that drives T cell exhaustion by pushing the cells to burn through their energy during cancer immunotherapy. Published in Immunity, animal and laboratory studies showed that blocking MEK helped T cells conserve energy, survive longer, and remain active in tumor environments. Since FDA-approved MEK inhibitors are already available, this approach could soon be tested in humans.
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