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Single dose of psychedelic nasal spray reduced treatment-resistant depression symptoms for eight weeks

PsyPost · 2026-10-31
🤖 AI-generated content — The title and summary were produced automatically by artificial intelligence, without human editorial review.

A JAMA trial reported that one dose of synthetic mebufotenin nasal spray eased treatment-resistant depression within a day, with benefits lasting up to eight weeks. Patients on the active dose improved more on a standard depression scale than those on a low comparator dose; most were assessed ready to leave the clinic within two hours after a brief psychoactive episode, unlike longer psilocybin sessions that need four to twelve hours in clinic.

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Source: PsyPost · via ahirlevel.hu

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