Johns Hopkins team identifies colon receptor for gut bacterium toxin linked to cancer
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A Johns Hopkins–led team reported in Nature that claudin-4 is where BFT, a toxin from Bacteroides fragilis, binds to intestinal cells—closing a nearly 20-year gap in how the common gut bacterium damages the colon and promotes tumors. They developed a molecular decoy that intercepts BFT and protected mice from its effects, pointing to possible prevention of bacterial damage tied to colorectal cancer.
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